Overview

My research sits at the interface between computer science and the life sciences, with a particular focus on bioinformatics and computational biology. I develop and apply computational tools and methods to address questions in genome annotation, metagenomics, and host–parasite interactions.

A recurring theme in my work is the challenge of finding and characterising genes that are missed or poorly represented by existing annotation tools — including small open reading frames (sORFs) and rare sequences in pan-genomes. I am also interested in the application of digital twin approaches to biological systems, and in the use of bioinformatics to support genome engineering and precision fermentation.

I collaborate closely with wet-lab scientists, and much of my work is motivated by real experimental and clinical questions.

• Genome annotation
• Lab automation, modelling and digital twins
• Genome engineering and precision fermentation
• Bioinformatics and computational biology

Trosolwg

Mae fy ymchwil yn eistedd ar y rhyngwyneb rhwng cyfrifiadureg a'r gwyddorau bywyd, gyda ffocws arbennig ar fio-wybodaetheg a bioleg gyfrifiadurol. Rwy'n datblygu ac yn cymhwyso offer a dulliau cyfrifiadurol i fynd i'r afael â chwestiynau ym maes anodiad genomau, metagenomeg, a rhyngweithiadau rhwng gwesteiwr a pharasite.

Thema sy'n dychwelyd yn fy ngwaith yw her canfod a nodweddu genynnau sy'n cael eu colli neu eu cynrychioli'n wael gan offer anodi presennol — gan gynnwys fframiau darllen agored bach (sORFs) a dilyniannu prin mewn pan-enomau. Mae gennyf hefyd ddiddordeb mewn cymhwyso dulliau efeilliaid digidol i systemau biolegol, ac mewn defnyddio bio-wybodaetheg i gefnogi peirianneg genomau ac eplesu manwl-gywir.

Rwy'n cydweithio'n agos â gwyddonwyr labordy gwlyb, ac mae llawer o fy ngwaith yn cael ei ysgogi gan gwestiynau arbrofol a chlinigol go iawn.

• Anodiad genomau
• Awtomeiddio labordy, modelu ac Efeilliaid digidol
• Peirianneg genom a eplesu manwl-gywir
• Biowybodeg a bioleg gyfrifiadurol

PhD Students

Myfyrwyr PhD

Publications

For a complete and up-to-date list, see my Google Scholar profile.

Cyhoeddiadau

Am restr gyflawn a chyfredol, gweler fy mhroffil Google Scholar.