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06/10/05

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My research focuses on the use of proteomic Two dimensional difference gel electrophoresis (2D -DiGE)  of the proteome of tsete fly gut contents demonstrating protein differences between a trypanosome-infected tsetse fly (red spots, Cy5 label) and a tsetse fly which has "self-cleared" it's trypanosme infection (green spots, Cy3). technologies to explore host-parasite interactions. My current interests are in developing two dimensional difference gel electrophoresis (2D DIGE) to unravel the complexities of innate immunity in a range of invertebrates and to explore the mechanisms used by parasites to overcome the host immune system.

                                                                                                            

Current projects:                                                                                            2D DIGE gel    

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Functional proteomic analyses of tsetse fly-trypanosome interactions. 

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Immunity in Achatina fulica, the Giant African land snail.

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Mechanisms of resistance and susceptibility to schistosome infection in Biomphalaria spp.

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The role arthropods in the transmission of human pathogens. 

http://www.aber.ac.uk/parasitology

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