Tudalen Gartref Bersonol - Iolo ap Gwynn - Personal Home Page

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[NODER: Fy marn bersonol a geir ar y dudalen hon ac nid yw ei chynnwys o angenrhaid yn adlewyrchu barn unai Sefydliad y Gwyddorau Biolegol na Phrifysgol Cymru, Aberystwyth.

PLEASE NOTE: This page contains my personal views and its contents do not necessarily represent the views of either the Institute of Biological Sciences or The University of Wales, Aberystwyth.]

Cyfeiriad e-bost: iag@aber.ac.uk

Addysg: Ysgol Eifionydd, Porthmadog; Coleg Prifysgol Cymru, Aberystwyth. BSc & PhD mewn Swoleg.

Aelodaeth o Sefydliadau Proffesiynol etc.: Cymrawd o'r ' Royal Microscopical Society'; Aelod o Y Gymdeithas Wyddonol Genedlaethol; Aelod o'r Institute of Advanced Motorists.

Diddordebau ymchwil: Microscopeg electron, a'i ddefnydd i ateb gwahanol broblemau. Dadansoddi delweddau fel dull o gael gwybodaeth ddefnyddiol o ddelweddau microscopaidd. Bywyd y gell, gyda diddordeb arbennig yn sut y mae'r seitosgerbwd yn allweddol ym mhrosesau'r gell, wedi ei amseru gan gyfnodau cylch y gell. Strwythur mewnol cartilag y benglin. Gwneir llawer o'r gwaith hwn mewn cyd-weithrediad â Canolfan Ymchwil AO yn Davos Platz, Y Swistir. Gweler rhai cyhoeddiadau diweddar .

Dysgu: Ym 1988 sefydlais y cwrs ôl-radd Diploma/MSc mewn Microscopeg Electron Biolegol. Hwn oedd yr unig un o'i fath yn Ewrop. Mae dysgu is-raddedigion yn cynnwys: Blwyddyn Gyntaf: Tiwtor blwyddyn gyntaf; Cyfrifiadura i fiolegwyr, Bywyd y Gell.; Ail flwyddyn: Bywyd y Gell a datblygiad anifeiliaid, systemau nerfol a symudiad infertebratau, Cyfrifiadura i fiolegwyr; Trydedd Blwyddyn: Arolygu prosiectau. Yn awr wedi ymddeol.

Peth gwaith allanol perthnasol: Cadeirydd Cyfarwyddwr Ymddiriedolwr i'r Ganolfan Dechnoleg Amgen . Aelod ac aelod o bwyllgor gwaith Y Gymdeithas Wyddonol Genedlaethol. Aelod o Gyngor Amgueddfa Cymru. Is-Gadeirydd o Awdurdod Parc Cenedlaethol Eryri- yn cynrychioloi'r Cynulliad Cenedlaethol; Aelod o Glwb Mynydda Cymru. Cyn-aelod, Ysgrifennydd a Chadeirydd o Fwrdd Hyfforddi Arweinwyr Mynydd Cymru..

Diddordebau eraill: Gwleidydda (Aelod o Blaid Cymru ers yn blentyn - Cyn-gadeirydd Pwyllgor Rhanbarth ac Asiant i Cynog Dafis a Simon Thomas). Mynydda, Sgio, Ffotograffiaeth a gwaith ymarferol.

Dyma rai Safleoedd diddorol a defnyddiol ar y We Fyd Eang:

• Tudalennau o gysylltiadau
• Tudalen Gartref Tref Davos, Graubunden/Grisons, Y Swistir.
• Plaid Cymru
• Y Gymuned Ewropeaidd
• Institute of Advanced Motorists
• Cymru ar y Rhyngrwyd
• Bwrdd Croeso Cymru
• Amgueddfa Cymru
• Parc Cenedlaethol Eryri
• TUDALEN GARTREF Sefydliad y Gwyddorau Biolegol

English version:

E-mail address: iag@aber.ac.uk

Education: Ysgol Eifionydd, Porthmadog; The University College of Wales, Aberystwyth. BSc & PhD in Zoology.

Membership of Professional Organisations etc.: Fellow of the Royal Microscopical Society; Member of Y Gymdeithas Wyddonol Genedlaethol (The Welsh Scientific Society); Member of The Institute of Advanced Motorists.

My name: For those who do not understand Cymric ways my name means Iolo son of Gwynn. i.e. 'ap' means 'son of'. My two sons are therefore called, respectively 'Llyr ap Iolo' and 'Rhys ap Iolo'. The feminine form 'ach' is rarely used and it is nowadays customary simply to omit it. Therefore my daughter is called 'Rhian Iolo'. There is no such thing as a surname, or family, name in our way of doing things. Some people use the mother's name instead, so Rhian could just have easily been called 'Rhian Ellen'. Many common 'surnames' in Wales are derived from this way of naming, e.g. Pritchard is derived from 'ap Rhisiart', Puw / Pugh is derived from 'ap Huw', Bevan is derived from 'ab Ifan' and Preece is derived from 'ap Rhys'. The same applies to 'Powell', 'Probert' & 'Prydderch'. 'ap Sion' became Jones, 'ab Ifan' also became Evans and 'ap Gwilym' became Williams. This all happened when the English administration imposed its ways upon us. Currently there is an increasing tendency amongst Welsh parents to revert to our traditional method of naming their offspring. Strictly speaking my eldest son should be called Llyr ap Iolo ap Gwynn ap Huw ap ........etc., thus following the male lineage in a family as far back as possible. 

Research interests: Electron microscopy, and its application to a variety of problems. Image analysis as a means of extracting useful information from microscopic images. Cell biology, with a special interest in how the cytoskeleton plays a key role in cellular processes, modulated by the cell cycle phases. The micromorphology of articular cartilage. Much of this work is carried out in collaboration with the AO Research Institute, Davos Platz, Switzerland. See recent publications.

Teaching: In 1988 the Biological Electron Microscopy postgraduate Diploma/MSc course was established. This was the only one of its kind in Europe. Undergraduate teaching comprises: First Year: First year tutor; IT for biologists; Cell Biology. Second Year: Cell and Developmental Biology, IT for Biologists, Invertebrate nervous systems and locomotion; Third Year: Project supervision. Now retired.

Some related outside work I have been or am involved with: Chair of the Trustees of the Centre for Alternative Technology. Member of the Executive Committee of 'Y Gymdeithas Wyddonol Genedlaethol' (The Welsh National Scientific Society). Member of the Council of the National Museum Wales. Vice-Chair of the Snowdonia National Park Authority; Former member, Secretary and Chair of The Wales Mountain Leader Training Board..

Other interests: Politics (Long-time member of Plaid Cymru - Past Chair of constituency party and election agent to Cynog Dafis AM and Simon Thomas MP,), Mountaineering, Skiing, Photography and DIY.

Some Links:

To learn more about Cymru / Wales:

• Pages of links
• Home page of Davos, Graubunden/Grisons, Switzerland.
• Plaid Cymru
• The European Union
• Institute of Advanced Motorists
• Wales on the Web
• Visit Wales
• Amgueddfa Cymru - NAtional Museum Wales
• Snowdonia National Park
• Institute of Biological Sciences home page

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Rhai cyhoeddiadau diweddar - Some recent publications

• Barlow,A.L., Jenkins,G & ap Gwynn, I. (1993) Scanning Electron Microscopy of Synaptonemal Complexes. Chromosome Research, 1, 9.
• Maybury, C.A. & ap Gwynn, I. (1993) Wet Processing of Recent Calcareous Foraminifera: Methods for Preventing Dissolution, J.Micropalaeon12, 67.
• ap Gwynn, I. (1994) Cell Biology at Interfaces, J. Materials Sci: Materials in Medicine, 5, 357.
• ap Gwynn,I (1994) Golygydd DELTA, 1.
• ap Gwynn,I., & R.G.Richards (1994) Backscattered Electron Detection as a Means of Studying Cell Adhesion by Scanning Electron Microscopy, ICEM 13, 131-132.
• ap Gwynn,I. & A.Eastham (1994) The Application of Neural Network Software to the Analysis of Patterns Recorded in SEM Images. Proc.Roy.Micr.Soc., 29, 235.
• ap Gwynn,I (1994) Golygydd DELTA, 2.
• ap Gwynn,I (1994) Golygydd Y GWYDDONYDD, 31.
• ap Gwynn,I (1995) Golygydd DELTA, 3.
• Cancio,I., ap Gwynn,I., Ireland,M.P. & Cajaraville,M.P. (1995) Lysosomal origin of the chloragosomes in the chloragogenous tissue of the earthworm Eisenia foetida: cytochemical demonstration of acid phosphatase activity. Histochemical Journal 27, 591-596.
• Richards, R.G., Rahn, B.A. & ap Gwynn, I. (1995) Scanning Electron Microscopy of the Undersurface of Cell Monolayers Grown on Metallic Implants, J. Materials Sci: Materials in Medicine 6, 120-124.
• Richards,R.G. & ap Gwynn,I (1995) Backscattered Electron Imaging of the undersurface of resin embedded cells by Field Emission Scanning Electron Microscopy. J.Microscopy, 177, 43-52.
• Cancio,I., ap Gwynn,I., Ireland,M.P. & Cajaraville,M.P. (1995) The Effect of sublethal lead exposure on the ultrastructure and on the distribution of acid phosphatase activity in chloragocytes of earthworms (Annelida, Oligochaeta) Histochemical Journal 27, 965-973.
• ap Gwynn,I (1995) Golygydd DELTA, 4.
• Richards, R.G., ap Gwynn, I., Bundy, K.J., & Rahn, B.A. (1995) Microjet impingement followed by scanning electron microscopy as a qualitative technique to compare cellular adhesion to various biomaterials. Cell Biology International 19, 1015-1024.
• Richards, R.G. & ap Gwynn, I., (1995) A Novel Method for viewing heavy metal stained and embedded biological tissue by field emission scanning electron microscopy. Scanning Microscopy 10, 111-119.
• Richards, R.G., Owen, G.Rh. & ap Gwynn, I. (1996) Backscattered electron imaging of biological samples at low beam potentials. Proc.Roy.Micr.Soc. 31, 142-143.
• ap Gwynn,I (1996) Golygydd DELTA, 5.
• Richards, R.G., Owen, G. Rh., ap Gwynn, I. & Gasser, B. (1996) Cell compatability of titanium implant surfaces assessed by fibroblast adhesion. Proc. 11th Euro.Cong.E.M., B4-5.
• Richards, R.G., Owen, G. Rh. & ap Gwynn, I. (1996) Low voltage backscattered electron imaging with a field emission SEM. Proc. 11th Euro.Cong.E.M., B5-7.
• Wilson, C.M. & ap Gwynn, I. (1996) Analysis and Characteristics of TEM images of metal particles. Proc. 11th Euro.Cong.E.M., B4-3.
• ap Gwynn, I. & Eastham, A. (1996) Classification of SEM images of bird egg shells by means of artificial neural networks. Proc. 11th Euro.Cong.E.M., GBM18.
• Richards RG, ap Gwynn I (1996) A novel method for viewing heavy metal stained and embedded biological tissue by field emission scanning electron microscopy. Scanning Microsc 10, 111-119.
• Richards RG, Owen GRh and ap Gwynn I. (1997) Backscattered electron imaging revisited. Microscopy and Analysis, 48 (EUR), 29-31.
• Richards RG, Owen GRh, Rahn BA and ap Gwynn I. (1997) A quantitative method of measuring cell adhesion areas. Review. Cells and Materials. 7, 15-30.
• ap Gwynn I (1997) Chemical Fixation for Electron Microscopy. 40 Godini Elektronske Mikroskopije u Srbiji. 105-108.
• Eastham A & ap Gwynn I (1997) Archaeology and the electron microscope. Eggshell and neural network analysis of images in the Neolithic. Anthropozoologica 25-26, 85-94.
• Richards RG, Owen GRh, Rahn BA and ap Gwynn I. (1997) A quantitative method of measuring cell adhesion areas. Review. Cells and Materials. 7, 15-30.
• Kääb MJ, ap Gwynn I & Nötzli HP (1998) Collagen fibre arrangement in the tibial plateau articular cartilage of man and other mammalian species. J. Anat. 193, 23-34.
• Gerber I, Peter R & ap Gwynn I (1998) The repetitive use of calvariae as a source of different osteoblasts. Swiss Society of Biomaterials 4th Annual Meeting, 31.
• Gerber I, Peter R & ap Gwynn I (1998) Bone and cartilage differentiation of periosteum-free calvariae in long-term organ culture. 6th International Conference on the Chemistry and Biology of Mineralized Tissues. 1.
• Gerber I, Peter R & ap Gwynn I (1998) The repetitive use of calvariae as a source of differentiating osteoblasts. 7th Workshop on Cell Biology of Bone and Cartilage in Health and Disease. C29:8S
• Gerber I, Peter R & ap Gwynn I (1998) The effect of serum on the differentiation of intact or denuded calvariae in organ culture. Swiss Bone and Mineral Society 14.05.98, Bern.
• Sewell J J, Hinchliffe J R & ap Gwynn I (1997-98) Early lysosomal activation and acid phosphatase enhancement in programmed developmental cell death of chick limb bud cells. Cancer Research Wales Report 1997/98 58-61.
• ap Gwynn I & Richards R G (1999) Adhesive interfaces between cells cultured on abraded titanium and steel - investigated by backscattered electron imaging. Synos Publications 1-A(1) III-2.
• ap Gwynn I & Wilson C (1999) The range of particle types produced by fretting implant materials used for internal fixation. Synos Publications 1-A(1) III-4.
• Kääb M J, Richards R G, Walther P, ap Gwynn I & Nötzli H P (1999) A Comparison of four preparation methods for the morphological study of articular cartilage for scanning electron microscopy. Scanning Microscopy 13, 61-70.
• Harris L G, ap Gwynn I & Richards R G (1999) Contrast optimisation for backscattered electron imaging of resin embedded cells. Scanning Microscopy 13, 71-81.
• Richards R G, Owen G Rh & ap Gwynn I (1999) Low voltage backscattered electron imaging using field emission scanning electron microscopy. Scanning Microscopy 13, 55-60.
• ap Gwynn I, Wade S, Kääb M J, Owen G Rh & Richards R G (2000) Freeze-substitution of rabbit tibial articular cartilage reveals that radial zone collagen fibres are tubules. J Microscopy 197, 159-172.
• Owen G Rh, Meredith D O, ap Gwynn I & Richards R G (2000) The relation between osteoblast adhesion and eventual mineralisation on implant materials. ASBMR 22nd Annual Meeting, Toronto 2000, SU199
• ap Gwynn I & Wilson C (2001) Characterizing fretting particles by analysis of SEM images. Euro.Cells Mat. 1 1-11.
• Richards RG, Stiffanic M, Owen GRh, Riehle M, ap Gwynn I, Curtis ASG (2001) Immunogold labelling of fibroblast focal adhesion sites visualised in fixed material using scanning electron microscopy and in vivo, using Internal Reflection Microscopy. Cell Biology International. 25, 1237-1249.
• Owen GRh, Meredith DO, ap Gwynn I, Richards RG (2001) Enhancement of immunogold-labelled focal adhesion sites in fibroblasts cultured on metal substrates: Problems and Solutions. Cell Biology International. 25, 1251-1259.
• ap Gwynn, I. (2001) Preservation of Tissue for Immunocytochemical Studies. In Immunocytochemistry and In Situ Hybridization in the Biomedical Sciences. Ed J E Beesley - Birkhauser pp 6-29.
• Gerber, I., & ap Gwynn, I. (2001) Influence of cell isolation, cell culture density, and cell nutrition on differentiation of rat calvarial osteoblast-like cells in vitro. Euro.Cells Mat. 2, 10-20.
• Owen, G Rh, Meredith, D O, ap Gwynn, I, & Richards, R G. (2001) Enhancement of immunogold labelled vinculin in cells cultured on metal implant surfaces Euro.Cells Mat. 1 (Suppl 1), 12-13.
• ap Gwynn, I. Specimen Preparation at ambient temperature. (2001) Euro.Cells Mat. 1 (Suppl 2), 4.
• ap Gwynn, I., Wade, S C & Richards, R.G. (2001) Preservation of articular cartilage for electron microscopy. Microscopy and Microanalysis 7 (Suppl 2) 726-727.
• Baxter L, Frauchiger V, Textor M, ap Gwynn I, Richards RG. (2002) Fibroblast and osteoblast adhesion and morphology on calcium phosphate surfaces.Euro.Cells Mat. 4 1-17.
• Owen G Rh, Meredith D O, ap Gwynn I, Richards RG. (2002) Simultaneously identifying S-phase labelled cells and immunogold-labelling of vinculin in focal adhesions. J.Microsc. 207, 27-36.
• I. Gerber and I. ap Gwynn (2002) Differentiation of rat osteoblast-like cells in monolayer and micromass cultures. Euro. Cells Mat. 3, 19-30.
• Evans, S., Bushell, A., Wade, S., ap Gwynn, I. and Evans, A. (2002) Surface composition and morphology of c-BN abd diamond microcrystals. Diamond Conference Abstracts.
• I. ap Gwynn, S. Wade, K. Ito and R.G. Richards (2002) Novel aspects to the structure of rabbit articular cartilage Euro. Cells Mat. 4, 18-29.
• Greaves, G. N., F. Menau, A. Sapelkin, L.M. Colyer, I. ap Gwynn and S. Wade (2003) The rheology of collapsing zeolites amorphised by temperature and pressure. Nature materials 2, 622-629.
• Kääb MJ, Richards RG, Ito K, ap Gwynn I, Nötzli HP. (2003) Deformation of Chondrocytes in Articular Cartilage under Compressive Load. A Morphologic Study. Cells Tissues Organs. 175(3):133-139.
• Meredith DO, Owen GRh., ap Gwynn I, Richards RG. (2004). Variation in cell-substratum adhesion in relation to cell cycle phases. Exp. Cell Res. 293, 58-67.
• Iatridis JC, ap Gwynn I. (2004) Mechanisms for mechanical damage in the intervertebral disc annulus fibrosus. J. Biomechanics 37(8), 1165-1175.
• Harris LG, Patterson LM, Bacon C, ap Gwynn I, Richards RG: (2005) Assessment of the cytocompatibility of different coated titanium surfaces to fibroblasts and osteoclasts. J Biomed Mater Res 73A: 12-20
• I. Gerber, I. ap Gwynn, M. Alini, T. Wallimann (2005) Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures Eur Cell Mater 10 8-22
• Owen, GRh, Meredith, DO, ap Gwynn, I and Richards, RG (2005) Focal adhesion quantification - A new assay of material biocompatibility? : Review Eur Cell Mater 9 85-96
• L. C. Hughes, C. W. Archer and I. ap Gwynn (2005) The ultrastructure of mouse articular cartilage: Collagen orientation and implications for tissue functionality. A polarised light and scanning electron microscope study and review. Eur Cell Mater 9 68-84
• Kääb M.J., Bail H.J., Rotter A., Mainil-Varlet P., ap Gwynn I., Weiler (2005) A.Monopolar Radiofrequency Treatment of Partial-Thickness Cartilage Defects in the Sheep Knee Joint leads to Extended Cartilage Injury . American Journal of Sports Medicine 33(10):1472-8.
  

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